IMR Press / EJGO / Volume 31 / Issue 1 / pii/1630984329171-1632907452

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Impact of three-dimensional (3D) ultrasonography and power Doppler angiography in the management of cervical cancer
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1 Department of Obstetrics and Gynecology, Toyota Memorial Hospital, Toyota Memorial Hospital, Toyota-shi
2 Department of Obstetrics and Gynecology, Wakayama Medical University, Kimiidera Wakayama-shi (Japan)
Eur. J. Gynaecol. Oncol. 2010, 31(1), 10–17;
Published: 10 February 2010
Abstract

Purpose: To evaluate the potential role of three-dimensional (3D) ultrasound, and to assess its diagnostic performance and ability to predict therapeutic efficacy in cervical cancer. Methods: Thirty patients with cervical cancer and 35 normal controls were studied by transvaginal 3D power Doppler ultrasound before treatment. Eleven patients who received neoadjuvant chemotherapy (n = 6), radiation (n = 3), or chemoradiation (n = 2), had further measurements taken one month and two months after treatment. Results: From the receiving operating characteristics curve analysis, the best vascularization index (VI) cutoff value of 5.24 distinguished cervical cancer from the normal cervix, with a sensitivity of 73.3% and a specificity of 94.3%. Cervical tumor volume measured by magnetic resonance imaging was positively correlated with the tumor volume measured by 3D ultrasonography (r = 0.91, p < 0.0001). In six patients who received neoadjuvant chemotherapy, the percent change in tumor volume during the second month of treatment was positively correlated with the percent change in flow index (FI) during the first month of treatment (r = 0.83, p < 0.05). Conclusions: VI may be a diagnostic marker and FI may be a predictive marker of treatment response in cervical cancer.
Keywords
Uterine cervical cancer
Three-dimensional imaging
Ultrasonography
Doppler ultrasound
Neoadjuvant chemotherapy
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