European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Genetic imbalance related to cisplatin-based chemoresistance in epithelial ovarian cancer
Purpose of investigation: To identify genetic imbalance related to chemoresistance in epithelial ovarian cancer. Methods: We screened abnormal chromosomal regions in cisplatin-resistant and cisplatin-sensitive human ovarian cancer cell lines employing comparative genomic hybridization (CGH). We also documented non-random chromosome gains and losses with cisplatin-resistant and cisplatinsensitive primary epithelial ovarian tumors from patients. Results: There were extensive chromosome changes in cisplatin-resistant and cisplatin-sensitive cell lines. Gains of lq 12-22, 17q21-22 and loss of 3p21-24 were significantly more common in drug-resistant tumors from patients compared to the drug-sensitive group. Conclusions: The special chromosomal aberrances might provide us with a clue for further investigation of the dominant mechanism that leads to a drug-resistant phenotype.