IMR Press / EJGO / Volume 30 / Issue 1 / pii/2009017

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Intraoperative estimation of sentinel lymph nodes in breast cancer by imprint cytology

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1 Department of Obstetrics & Gynecology, Democritus University of Thrace (Greece)
2 Department of Surger, Democritus University of Thrace (Greece)
3 Department of Obstetrics & Gynecology, Regional Hospital of Alexandroupolis (Greece)
4 Department of Histology-Embryology, Democritus University of Thrace (Greece)
5 Depariment of Pathologs, Ippocration General Hospital of Salonica (Greece)
6 Department of Experimental Surgery, Democritus University of Thrace (Greece)
Eur. J. Gynaecol. Oncol. 2009, 30(1), 79–81;
Published: 10 February 2009

Background: Frozen section biopsy has been widely used for intraoperative diagnosis and evaluation of sentinel lymph nodes, so a decision can be made regarding whether to perform axillary clearance during primary surgery. This study aims to discuss the reliability of a simpler and faster method - touch imprint cytology - in the interpretation of metastasis from breast cancer. Methods: A retrospective review of 41 sentinel lymph node biopsies from patients with breast cancer were examined by intraoperative imprint cytology using rapid Diff-Quick staining. Paraffin-embedded permanent sections were examined using hematoxylin and eosin stained sections from the sentinel lymph nodes in collaboration with the employment of an anti-cytokeratin antibody. Results: Sixteen of all sentinel nodes harbored metastases in the paraffin sections, of which all 16 were identified by imprint cytology (sensitivity 93%). Conclusion: Touch imprint cytology is a fast and reliable alternative for intraoperative evaluation of sentinel lymph nodes in breast cancer patients.

Breast cancer
Sentinel lymph node
Imprint cytology
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