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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Original Research
Fascin can be an auxiliary immunomarker of ovarian granulosa cell tumors: comparison with calretinin and inhibin-α
E. Kostopoulou1,*, S. Angelidou2, A. Daponte3, C. Galani1, I. Chiotoglou4, A. Terzis1, G. Koukoulisa1
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1
Department of Pathology, University Hospital of Larissa, Medical School of Thessaly, Larissa
2
Department of Pathology, Hippokration Hospital of Thessaloniki, Thessaloniki
3
Department of Obstetrics and Gynecology, University Hospital of Larissa, Medical School of Thessalia, Larissa
4
Laboratory of Cytogenetics and Molecular Genetics, University Hospital of Larissa, Larissa (Greece)
Eur. J. Gynaecol. Oncol. 2008, 29(6), 638–642;
Published: 10 December 2008
Abstract
The histopathologic diagnosis of granulosa cell tumor adult type (AGCT) can be supported by the use of established immunomarkers such as inhibin-α and calretinin. Previously unreported data is presented on the detection of fascin in AGCT, in nonneoplastic granulosa cells and in other types of sex-cord stromal tumors. In addition, by staining a panel of various tumors, potentially included in the differential diagnosis of AGCT, we assessed the value of fascin as an auxiliary AGCT immunomarker. Intense and strong fascin staining may assist in cases with ambiguous calretinin or inhibin-α staining. On the contrary, absence of fascin should question a provisional morphologic diagnosis of AGCT.
Keywords
Fascin
Ovary
Granulosa
Immunohistochemistry
Inhibin-α
Calretinin