IMR Press / EJGO / Volume 29 / Issue 6 / pii/1631005525201-1952719903

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Tamoxifen in women with breast cancer and mammographic density
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1 Department of Gynecology, Perinatology and Child Health, University of Rome, Rome
2 Department of Experimental Medicine and Pathology, University of Rome, Rome
3 Department of Radiological Sciences “Sapienza”, University of Rome, Rome (Italy)
Eur. J. Gynaecol. Oncol. 2008, 29(6), 598–601;
Published: 10 December 2008

Purpose of investigation: To evaluate the effect of tamoxifen on mammographic density using a qualitative and a semiquantitative method. Methods: Mammograms from 148 women treated for breast cancer before and after surgery were reviewed: 68 were administered tamoxifen; 80 did not receive tamoxifen. The mammograms were classified in one of the four BIRADS density categories by two radiologists blinded to the treatment and by a computer-assisted method after digitizing images. Results: At mammographic one-year-follow-up density was reduced in both groups and remained stable in the following years. A comparison of mammograms performed before surgery and after one year showed a statistically significant difference in density reduction between the tamoxifen and the non-tamoxifen-treated group. Good agreement was obtained between the qualitative and semiquantitative method. Conclusion: Breast density reduction observed in women treated with tamoxifen may help in the detection of small tumors in dense breasts by means of reducing the masking effect of parenchyma.
Mammographic density
Breast cancer
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