IMR Press / EJGO / Volume 29 / Issue 5 / pii/1631004252863-1545423316

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Immunohistochemical expression of MMP-2, MMP-9 and COX-2 in Stage IA malignant polyps of the endometrium
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1 Department of Obstetrics and Gynecology, Faculty of Medicine, University of Süleyman Demirel, Isparta
2 Department of Pathology, Faculty of Medicine, University of Süleyman Demirel, Isparta (Turkey)
Eur. J. Gynaecol. Oncol. 2008, 29(5), 444–449;
Published: 10 October 2008

Objective: To study whether endometrioid type malignant endometrial polyps (MEP) are different from endometrium cancer not associated with polyps (ECNAP) in means of immunohistochemical expressions of MMP-2, MMP-9 and COX-2. Methods: Archived tissue samples of eight MEP, eight ECNAP and 16 benign endometrial polyps were selected and immunohistochemically analyzed for MMP-2, MMP-9 and COX-2 expression. Results: MMP-2 and MMP-9 were overexpressed in ECNAP compared to MEP and benign endometrial polyps (p < 0.05). MMP-2 and MMP-9 expressions were not different in the malignant part of MEP, benign part of MEP and benign endometrial polyps. COX-2 expression was found to be higher in benign lesions, although this was not statistically significant. Conclusion: Similar immunohistochemical expression of MMP-2, MMP-9 and COX-2 within a polyp and with benign polyps may indicate an immunohistochemically indolent characteristic of MEP.
Endometrial polyp
Endometrium cancer
Cyclooxygenase 2
Matrix metalloproteinase 2
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