IMR Press / EJGO / Volume 29 / Issue 3 / pii/1630995588233-578849134

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.

Original Research
Prognostic factors in patients with carcinoma of the vulva – our own experience and literature review
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1 Center of Oncology, Gynecologic Oncology Department, M. Sklodowska-Curie Memorial Institute, Krakow Branch
2 Center of Oncology, Medical Oncology Department, M. Sklodowska-Curie Memorial Institute, Krakow Branch
3 Students’ Scientific Society of the Medical College of Jagiellonian University
4 Krakow Medical Center, Krakow (Poland)
Eur. J. Gynaecol. Oncol. 2008, 29(3), 260–263;
Published: 10 June 2008
Abstract

Aim of the study: The objective was the analysis of prognostic factors and treatment outcomes of 104 patients with vulvar cancer, treated between 1990 and 2003 in the Center of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow, Poland. Material and Methods: The median age of patients was 67. Advanced disease (TNM III and IVA) was found in 54 (51.9%) patients and grade 2 and 2 in 50 (48.1%). Inguinal lymph nodes were clinically uni- or bilaterally involved in 40.4% of patients. Fifty-seven (54.8%) patients underwent radical vulvectomy with bilateral inguinal lymphadenectomy and 47 (45.2%) radical vulvectomy only. Cancer differentiation was well in 38 (36.2%) of patients, moderate in 38 (36.2%) and poor in 28 (36.6%). Adjuvant radiotherapy was applied in 30 (28.8%) cases. Results: Five-year overall survival rate was observed in 44.4% of patients. Depending on TNM grade, 5-year OS rates were 61.4% for grade 1, 54.9% for grade 2, 40.1% for grade 3 and 13.3% for IVA. In patients aged <70, 5-year OS rate was 54.7% compared to 30.5% for those ≥70. Among patients with G1 cancer differentiation 64.4% survived five years, with G2 39.1% and with G3 24.9%, respectively. Conclusion: Univariate analysis revealed a statistically significant, unfavorable impact of age ≥70, with G3 cancer differentiation, clinically confirmed inguinal lymph node involvement and TNM classification stage on 5- year overall survival. Cox multivariate analysis demonstrated that independent prognostic factors for 5-year survival were the age of the patient, clinical status of inguinal lymph nodes and TNM classification grade.
Keywords
Carcinoma of the vulva
Prognostic factors
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