IMR Press / EJGO / Volume 29 / Issue 3 / pii/1630995583863-1134421165

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research
Sentinel lymph nodes in endometrial cancer: is hysteroscopic injection valid?
D. Clement1,4A. S. Bats1,4, N. Ghazzar-Pierquet2M. A. Le Frere Belda3,4F. Larousserie1,4C. Nos1,4F. Lecuru1,4,*
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1 Service de Chirurgie Gynécologique et Cancérologique, Hôpital Européen Georges Pompidou
2 Département de Médecine Nucléaire, Hôpital Européen Georges Pompidou
3 Service d’Anatomie Pathologique, Hôpital Européen Georges Pompidou
4 Université Paris-Descartes, Faculté de Médecine, Paris (France)
Eur. J. Gynaecol. Oncol. 2008, 29(3), 239–241;
Published: 10 June 2008

We aimed to describe hysteroscopic peritumoral tracer injection for detecting sentinel lymph nodes (SLNs) in patients with endometrial cancer and to evaluate tolerance of the procedure, detection rate and location of SLNs. Five patients with early endometrial cancer underwent hysteroscopic radiotracer injection followed by lymphoscintigraphy, then by surgery with hysteroscopic peritumoral blue dye injection, and radioactivity measurement using an endoscopic handheld gamma probe. SLNs and other nodes were sent separately to the pathology laboratory. SLNs were evaluated by hematoxylin-eosin-saffron staining and, when negative, by immunohistochemistry. Tolerance of the injection by the patients was poor (mean visual analog scale score, 8/10). SLNs were detected in only two patients (external iliac and common iliac+paraaortic, respectively). Detection rates were 1/5 by radiotracer, 1/5 by dye, and 2/5 by the combined method. One SLN was involved in a patient whose other nodes were negative. In three patients no SLNs were found by radiotracer or blue dye. Of the 83 non sentinel nodes removed from these patients, none was involved. Hysteroscopic peritumoral injection may be more difficult than cervical injection and, in our experience, carries a lower SLN detection rate.
Endometrial cancer
Sentinel lymph node
Paraaortic chain
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