IMR Press / EJGO / Volume 28 / Issue 6 / pii/2007226

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Does the copper intrauterine device affect serum cancer antigen 125 levels?

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1 Department of Obstetrics and Gynecology, Kajkas University Medical Faculty, Kars, Turkey
2 Department of Obstetrics and Gynecology,Firat University Medical Faculty, Elazig, Turkey
Eur. J. Gynaecol. Oncol. 2007, 28(6), 524–525;
Published: 10 December 2007

Purpose: This study aimed to reveal the effect of the copper IUD, if any, on serum CA-125 levels in patients who use the device as a contraceptive. Methods: Blood samples were obtained two times from 20 healthy volunteers before and after IUD insertion, and sera were isolated. The sera, centrifuged at 2000 G and kept at-70°C in a deep freezer until analyzed, were processed for CA-125 levels by the CA-125 kit using VIDAS PC analyzer (Biomerieux, France) and results were compared. Results: The CA-125 level of the serum obtained from the first blood samples was significantly higher than that of the second sample (24.63 ± 25.40 mIU/mL and 14.44 ± 10.08 mIU/mL, respectively) (p < 0.05). Conclusion: The results of this study indicate that the serum level of CA-125 may be lower in patients using copper IUDs which may be helpful in evaluation of ovarian masses in women in reproductive age.

Copper IUD
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