IMR Press / EJGO / Volume 28 / Issue 6 / pii/2007205

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Genetic imbalance and human papillomavirus states in vulvar squamous cell carcinomas

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1 Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China
Eur. J. Gynaecol. Oncol. 2007, 28(6), 442–446;
Published: 10 December 2007

Purpose of investigation: Vulvar squamous cell carcinoma (VSCC) is a disease of significant clinical importance, which arises in the presence or absence of human papillomavirus (HPV). Methods: We used comparative genomic hybridization (CGH) to document non-random chromosomal gains and losses with HPV positive and negative VSCCs. Results: Gains of 3q and 12q were significant­ly more common in HPV-positive cancers compared to HPV-negative cancers where chromosome Sq was more commonly gained in HPV-negative compared to HPV-positive cancer chromosomes and, 4p and 3p were lost in both categories of VSCCs. Conclusions: The data indicate that one or more oncogenes important in the development and progression of HPV-induced carcinomas are locat­ed on 3q and 12q.

Vulvar squamous cell carcinomas (VSCC)
Comparative genomic hybridization (CGH)
Human papillomavirus (HPV)
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