IMR Press / EJGO / Volume 28 / Issue 3 / pii/2007160

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report

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1 Department of Obstetrics and Gynecology, Haseki Education and Research Hospital, Istanbul, Turkey
2 Department of Oncology, Haseki Education and Research Hospital, Istanbul, Turkey
3 Department of Pathology, Haseki Education and Research Hospital, Istanbul, Turkey
4 Department of Pathology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
Eur. J. Gynaecol. Oncol. 2007, 28(3), 241–244;
Published: 10 June 2007

Background: Alpha-fetoprotein (AFP) is a useful tumor marker for germ cell tumors of the ovary and is valuable for both diag­nosis and follow-up. However, it is very rare for an epithelial ovarian carcinoma to secrete AFP. Case: We report a case of a 63-year-old woman with a ovarian clear cell carcinoma with serous component of less than 10%. Both histological components were producing AFP as demonstrated by immunohistochemistry. After surgery and chemotherapy, AFP decreased to normal range. The patient also had elevated CA-125 levels but the tumor was negative for CA-125 which sug­gested the increased CA-125 might have been due to the associated ascites. Conclusion: Ovarian clear cell type carcinomas rarely secrete only AFP and it might be the single marker that could be used in follow-up.

Clear cell carcinoma
Serous adenocarcinoma
Epithelial ovarian carcinoma
Tumor marker
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