IMR Press / EJGO / Volume 28 / Issue 2 / pii/2007132

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

“Occult” neuroendocrine component and rare metastatic pattern in cervical cancer: Report of a case and brief review of the literature

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1 Department of Obstelrics and Gynecology, University of Cologne School of Medicine, Cologne, Germany
2 Depanment of Obstetrics and Gynecology, St. Elisabeth Hospital, Cologne, Germany
3 Departmenl of Radiology, University of Cologne School of Medicine, Cologne, Germany
4 Departmenl of Radiology, University of Cologne School of Medicine, Cologne, Germany
5 Department of Obstetrics and Gynecology, Florence Nightingale Hospital, Düsseldorf, Germany
Eur. J. Gynaecol. Oncol. 2007, 28(2), 139–141;
Published: 10 April 2007

Distant metastases in small cell carcinomas of the uterine cervix are rare, and a disseminated manifestation of the disease is uncommon.

This is a case report of a 40-year-old woman treated with platin-based radio-chemotherapy for a moderately differentiated squa­mous cell cervical cancer FIGO Stage IB 1 (with positive paraaortic lymph nodes). One year later she presented with remarkably unusual cutaneous metastases of the left thumb and scalp as the first signs of spread of disease, including kidney, lung and brain metastases. An advanced retrospective immunohistochemical staining of the cervical biopsy discovered a small neuroendocrine component of the carcinoma as the presumably causative factor for the rare metastastic pattern and poor prognosis.

Cervical cancer
Squamous cell carcinoma
Staging lym­phadenectomy
Neuroendocrine carcinoma
Thumb metastasis
Renal metastases
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