IMR Press / EJGO / Volume 27 / Issue 3 / pii/2006156

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.


Breast cancer treatment - later pregnancy and survival

Show Less
1 Clinic of Gynaecology and Obstetrics, School of Medicine, University of Zagreb, Zagreb, Croatia
Eur. J. Gynaecol. Oncol. 2006, 27(3), 225–229;
Published: 10 June 2006

Although breast cancer (BC) affects patients at older age, it occurs more frequently in premenopausal women due to better diag­nostic methods and an increasing trend towards delay in childbearing. The increasing population of women with BC delaying child­bearing may be of concern regarding the effect of treatment on later pregnancy, as well as the influence of pregnancy on the prog­nosis of disease and survival. Radiotherapy has shown no adverse effects on the clinical outcome in the offspring except diminished lactation. The offspring of patients who became pregnant after chemotherapy have shown no congenital anomalies, although some­times a high abortion rate (10-29%) has been demonstrated. Currently, several fertility-sparing options, including the use of endocrine therapy and assisted reproductive technologies, cryopreservation and ovarian tissue transplantation, are very promising. The survival of BC patients is not decreased by a subsequent pregnancy; compared with the non-pregnant group their survival rates are often the same or better, with favourable relative risks and lower recurrence of metastases.

Breast cancer
Back to top