IMR Press / EJGO / Volume 27 / Issue 1 / pii/2006116

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Immunohistochemical detection of HPV proteins and c-erbB receptors in cervical lesion specimens from young women

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1 Department of Pathology, Patras University Hospital, Rion, Greece
2 Department of Obstetrics and Gynecology, Patras University Hospital, Rion, Greece
Eur. J. Gynaecol. Oncol. 2006, 27(1), 69–71;
Published: 10 February 2006

The intention of the present study was to assess immunohistochemically the expression of c-erbB receptor family in cervical car­cinoma specimens of young women. Simultaneously, HPV was detected in the same specimens using immunohistochemical assays. Seventy-five cervical intraepithelial and invasive cancer specimens were assessed retrospectively. Positive c-erbB-2 immunos­taining was revealed in 11.7% of tumor specimens, while for c-erbB-3 and c-erbB-4 receptor the corresponding figures were 32% and 49.3%, respectively. Concerning HPV infection-markers, positive immunostaining was found in 31 % of cases, while coilocytes were detected in 64% of patients. The correlation of c-erbB receptor expression with malignant aggressiveness in cervical cancer cells concurs with similar data regarding other neoplasias, thus rendering these receptors an important predictive factor and future therapeutic target.

c-erbB over-expression
Cervical cancer
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