IMR Press / EJGO / Volume 26 / Issue 6 / pii/2005251

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Fascin, an actin-bundling protein expression in cervical neoplasms

Show Less
1 Departments of Pathology, Osmangazi University, Eskisehir (Turkey)
2 Departments of Gynecology and Obstetrics and, Departments of Biostatistics, Osmangazi University, Eskisehir (Turkey)
3 Departments of Biostatistics, Osmangazi University, Eskisehir (Turkey)
Eur. J. Gynaecol. Oncol. 2005, 26(6), 636–641;
Published: 10 December 2005

Purpose of investigation: Our objectives were (1) to examine expression of fascin in cervical tissues with chronic inflammation, intraepithelial neoplasms and invasive carcinomas, and (2) to investigate the role of fascin on endothelial migration and angiogen­esis in cervical neoplasms. Methods: In this study we investigated by means of immunohistochemistry fascin expression in 92 cervical biopsy samples rep­resentative of chronic inflammation (n= 13), squamous intraepithelial lesions (SILs, n = 33) and invasive carcinomas (n = 46). Results: Various degrees of fascin expression were observed in 94% of the samples of SILs, in 67% of the samples of invasive cervical carcinoma and in 69% of the samples of chronic inflammation. Total epithelial fascin scores of samples were significantly higher in high-grade (H)SILs compared to low-grade (L)SILs, invasive carcinoma and chronic inflammation of the cervix (p < 0.05) Mean microvessel count was 55.00 ± 5.17 in HSILs, 40.76 ± 3.57 in LSILs, 37.11 ± 2.91 in carcinoma and 25.69 ± 3.98 in chronic inflammation. We found a significantly higher microvessel count in HSILs compared to invasive carcinoma and chronic inflammation (respectively, p =.004, p =.000). Conclusion: Epithelial fascin expression up-regulated when the malignant tumor cell phenotype had occurred in the cervix. Similarly, microvessel count increased with the beginning of cervical tumorigenesis.

Cervical neoplasms
Back to top