IMR Press / EJGO / Volume 26 / Issue 6 / pii/2005245

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Squamous intraepithelial lesion - microinvasive carcinoma of the cervix during pregnancy

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1 Division of Gynecologic Oncology; Department of Obstetrics and Gynecology, Prague (Czech Republic)
2 Department of Pathological Anatomy; The Charles University Prague, 2nd Medical Faculty, Prague (Czech Republic)
Eur. J. Gynaecol. Oncol. 2005, 26(6), 611–614;
Published: 10 December 2005

Objective: The objective of this work was to assess proper management of squamous intraepithelial lesion (SIL) and microinva­sive carcinoma during and after pregnancy, to assess risks of punch biopsy and conization in pregnancy and . to assess regression, persistence and risk of progression with low-grade (L) and high-grade (H) SIL. Methods: We carried out a prospective study of 167 pregnant women from our colposcopic unit who were referred to us for abnormal cytological findings between 1997 and 2002. The diagnosis of precancerosis was verified in all of the women by punch biopsy, suspect microinvasive carcinoma needle or LETZ conization up to the 20th week of pregnancy. All women were followed-up during the pregnancy and 24 months after their deliveries. Results: In 23 women with suspect early invasion we performed conization during the pregnancy (weeks 13-23). There were six cases (26.1 %) of microinvasive carcinoma and 17 cases (73.9%) of HSIL. One pregnancy aborted two days after the conization. No other obstetrical complications were recorded and there were no premature deliveries. Eighty-two women with HSIL were only followed-up during their pregnancy. We observed complete regression of HSIL during the study in 14 patients (22.6%), regression to LSIL in 17 patients (27.4%), persistence in 25 patients (40.3%) and progression to microcarcinoma in six cases (9.7%). Eighty-two patients were followed up for LSIL. Complete regression of LSIL was observed during the study in 40 cases (48.8%), persistence in 24 cases (29.2%) and progression to HSIL in 18 cases (22.0%). Conclusion: For LSIL and HSIL during pregnancy the above follow-up is a sufficient and safe protocol. Suspect microinvasive carcinoma should be treated by conization, which is a safe procedure until the 24th week of pregnancy.

Squamous intraepithelial lesion
Punch biopsy
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