IMR Press / EJGO / Volume 26 / Issue 2 / pii/2005145

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

BRCA 1 mutation, leptin and estrogen levels in breast cancer patients

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1 Chair and Department of Gynecological Surgery and Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin (Poland)
2 Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin (Poland)
Eur. J. Gynaecol. Oncol. 2005, 26(2), 205–206;
Published: 10 April 2005

Pre- and postmenopausal patients with breast cancer were screened for mutation of the BRCAl gene and estrogens and leptin levels were measured. In postmenopausal BRCAI mutation carriers, leptin levels were significantly lower and correlated with the body mass index (BMI). No significant difference in leptin levels was revealed between pre- and postmenopausal patients. Our findings suggest the existence of an alternative mechanism responsible for carcinogenesis in breast cancer patients with a genetic background.

BRCA I mutation
Breast cancer
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