European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
BRCA 1 mutation, leptin and estrogen levels in breast cancer patients
Pre- and postmenopausal patients with breast cancer were screened for mutation of the BRCAl gene and estrogens and leptin levels were measured. In postmenopausal BRCAI mutation carriers, leptin levels were significantly lower and correlated with the body mass index (BMI). No significant difference in leptin levels was revealed between pre- and postmenopausal patients. Our findings suggest the existence of an alternative mechanism responsible for carcinogenesis in breast cancer patients with a genetic background.