IMR Press / EJGO / Volume 26 / Issue 1 / pii/2005111

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Risk factors and prognostic factors in patients with double primary cancer: Epithelial ovarian cancer and breast cancer

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1 Institute of Oncology,Department of Gynaecology and Obstetrics, University Medical Center, Ljubljana, Slovenia
2 Department of Gynaecology and Obstetrics, University Medical Center, Ljubljana, Slovenia
Eur. J. Gynaecol. Oncol. 2005, 26(1), 59–63;
Published: 10 February 2005

Background and Objective: The most important known risk factor for ovarian cancer is the BRCAl-2 mutation, which is clini­cally often manifested through a positive family history of cancer of the breast and/or ovary. Whether other risk factors and prog­nostic factors in women with a positive family history of cancer of the breast and/or ovary and/or with BRCA 1-2 mutation are impor­tant remains to be elucidated. Recent studies have shown that in the double primary breast and ovarian cancer (DPBOC), BRCAl-2 mutation is present in at least 86% of cases. Therefore, the group of patients with DPBOC, especially with epithelial ovarian cancer and breast cancer, is the most suitable for such an analysis. The aim of this study was to verify the hypothesis that, in this group, some other risk factors, in addition to a specific family history of cancer, as well as unfavourable pathomorphological prognostic factors, are more expressed than in a control group of patients with sporadic epithelial ovarian cancer only. Methods: We compared the study group of 31 patients with DPBOC (epithelial ovarian cancer) to a control group of 62 patients with a single, sporadic epithelial ovarian cancer and negative specific family history. The data were obtained from the Cancer Reg­istry of Slovenia and from clinical records. For every patient, we filled-in a protocol and analysed the data, comparing other risk factors in addition to specific family history and prognostic, clinical, and pathomorphological factors. Statistical analysis was per­formed using descriptive statistics, chi-square test and t-test. Multivariate analysis was also planned, but the necessary conditions were not met. Results: In the study group, we found a higher percentage of positive non-specific family histories than in the control group, but the difference was not statistically significant. No difference in procreative risk factors was observed between the groups. There was a higher percentage of borderline significance of women from the study group that developed ovarian cancer between 45 and 59 years of age. In the study group, ovarian cancer was significantly more often found at Stage I, although the groups did not differ in detection procedures. Also, we did not find any differences in the distribution of tumour grades or histologic tumour types Conclusion: The results did not confirm our hypothesis, yet they indicated some differences between the groups regarding the risk factors for ovarian cancer. Regarding the prognostic factors, we even found a significantly higher percentage of Stage I epithe­lial ovarian cancer in the study group, with no difference in the mode of detection. Considering the results that are not typical of BRCA-related cancer (what double primary cancer of the ovary and breast is supposed to be) and previous reports, we find it more likely that the patients with BRCA 1-2 mutations represent only a subgroup within the group of patients with double primary breast and ovarian cancer.

Ovarian cancer
Breast cancer
Double primary cancer
Risk factors
Prognostic factors
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