IMR Press / EJGO / Volume 26 / Issue 1 / pii/2005105

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Primary lymphoma of the cervix uteri: a diagnostic challenge. Report of two cases and review of the literature

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1 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology and Ghent University Hospital, Ghent, Belgium
2 Department of Pathology, Ghent University Hospital, Ghent, Belgium
3 Department of Pathology, University Hospital Free University Brussels, Brussels, Belgium
Eur. J. Gynaecol. Oncol. 2005, 26(1), 36–38;
Published: 10 February 2005

Background: Primary non Hodgkin's lymphoma (NHL) of the cervix and vagina is uncommon; the incidence of uterine lymphoma is estimated to be less than 0.5% of all NHL. Patients regularly present with vaginal bleeding. The diagnosis is made on biopsy but this can be difficult on small samples which may not be representative of the lesion. Immunohistochemical analysis and often molecular techniques are required to confirm the diagnosis. Cases: We report two cases of primary diffuse large B-cell lymphoma of the cervix. In the first case, the diagnosis could only be made on repeat biopsies. The second case presented as a cervical polyp. Conclusion: Gynecologists should be aware of this rare clinical entity in order to apply the proper treatment.

Malignant lymphoma
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