IMR Press / EJGO / Volume 25 / Issue 5 / pii/2004247

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Atypical squamous cells: improvement in cytohistological correlation by the 2001 Bethesda System

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1 Department of Obstetrics and Gynecology, Zeynep Kamil Women and Children's Disease Education and Research Hospital, Uskudar/Istanbul (Turkey)
Eur. J. Gynaecol. Oncol. 2004, 25(5), 615–618;
Published: 10 October 2004

Purpose of investigation: To evaluate the advantages of the 2001 Bethesda System over the 1991 Bethesda System in the manage­ment of atypical squamous cells. Methods: The cytology files of the 8,748 patients were reviewed for diagnosis of atypical squamous cells of undetermined signifi­cance (ASCUS) at Zeynep Kami! Hospital. Seventy-two of the 259 smear specimens with the diagnosis of ASCUS were reviewed and reclassified according to Bethesda 2001. Results: Of the 8,748 specimens, 259 (2.96%) were diagnosed as ASCUS. In re-evaluation of the 72 specimens according to the 2001 Bethesda system, the number of cervical smears with a diagnosis of atypical squamous cells (ASC) decreased to 21 in number. Of the 21 cervical smears with an ASC category, eight patients (38.1%) had high-grade intraepithelial squamous lesions (HSIL) and six (28.6%) had low-grade intraepithelial squamous lesions (LSIL) in histopathological specimens. The detection rates of squamous abnor­malities (χ2 = 24.79, p < 0.0001) and high-grade squamous abnormalities (χ2 = 8.31, p = 0.0039) were significantly higher according to Bethesda 2001. Conclusion: The 2001 Bethesda System seems to reduce the number of cervical smear diagnoses of ASC, without causing any impairment in the diagnosis of HSIL thus decreasing the number of unneccesary interventions like cervical biopsy and decreasing the cost, inconvenience, anxiety and discomfort.

Atypical squamous cells
1991 Bethesda system
2001 Bethesda system
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