IMR Press / EJGO / Volume 25 / Issue 4 / pii/2004211

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Immunohistochemical profile of intravenous leiomyomatosis

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1 Department of Pathology, Zeynep Kami/ Maternity Hospital, Istanbul (Turkey)
2 Obstetrics and Gynecology, Zeynep Kami/ Maternity Hospital, Istanbul (Turkey)
Eur. J. Gynaecol. Oncol. 2004, 25(4), 481–483;
Published: 10 August 2004

To determine the immunohistochemical staining profile of intravenous leiomyomatosis (IVL), we analysed six IVLs and 12 ordi­nary leiomyomas (LM) for immunoreactivity with a panel of 11 antibodies. All IVLs and LMs reacted with antibodies to a-smooth muscle actin (, h caldesmon, vimentin and progesterone receptor (PR). Five of six IVLs and all LMs reacted with desmin. All IVLs were negative for CD-10. Only one LM exhibited focal CD-10 positivity. Three of six IVLs and nine of 12 LMs showed estrogen receptor expression. All IVLs and LMs showed immunnegativity with MIB-1 and inhibin. There were not any significant differences between immunoreactivity patterns of IVL and LM for asm, desmin, h caldesmon, CD-10, MIB-1 and PR. We conclude that, although they appear to be useful markers in differentiating IVL from ESS and LMS, a larger study also including ESS and LMS would be necessary to confirm their validity.

Endometrial stromal sarcoma
Estrogen receptor
Progesterone receptor
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