European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
The effect of recombinant GM-CSF on IL-6 and TNF-a levels in epithelial ovarian cancer patients who received paclitaxel and cisplatinum: preliminary results
Objective: We investigated the effects of GM-CSF factor on IL-6 and TNF-a levels prior to paclitaxel-cisplatinum combination chemotherapy for advanced epithelial ovarian cancer. Materials and Methods: Twenty-three consecutive patients with FIGO (International Federation of Gynecology and Obstetrics) Stage III-IV epithelial ovarian cancer were enrolled in the study. Following cytoreductive surgery patients received 175 mg/m2 paclitaxel and 75 mg/m2 cisplatinum on the same day. These 23 patients also received RhuGM-CSF five days before at a dose of 5 µg/kg/day by subcutaneous injection for three days. IL-6 and TNF-a levels were measured before and 24 hours later following the last dose of RhuGM-CSF. Results: White blood cell counts on the 10th day of the cycle were lower than preGM-CSF white blood cell counts and the difference was statistically significant (p = 0.003). Platelet levels on the 10th day of the chemotherapy cycle were lower than pre GMCSF levels, however were not statistically significant (p = 0.097). Post GM-CSF TNF-α and IL-6 levels were higher than pre GMCSF levels. This difference was statistically significant for TNF-α (p = 0.002) however for IL-6 a statistically significant difference was not detected (p = 0.55). GM-CSF does not significantly effect IL-6 levels in contrast to TNF-a. Conclusion: Clinical implications of increased levels of TNF-a are unclear and for a precise determination further studies are needed.