IMR Press / EJGO / Volume 25 / Issue 4 / pii/2004207

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Expression of beta-human chorionic gonadotropin in ovarian cancer tissue

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1 Division of Obstetric and Gynecology, Department of Gynecologic Oncology, University of Medical Science, Poznan (Poland)
2 Department of Radiobiology and Cell Biology, University of Medical Science, Poznan (Poland)
Eur. J. Gynaecol. Oncol. 2004, 25(4), 465–469;
Published: 10 August 2004

The purpose of the present investigation was to determinate expression of human chorionic gonadotropin gene in ovarian cancer tissue. The study included 15 patients with epithelial ovarian carcinoma. The expression of mRNA hCGβ was determinated by the RT PCR method and the distribution of the hormone in study tissue was analyzed immunohistochemicaly. In all 15 study specimens of the ovarian carcinoma tissue the active hCGβ gene was found, whereas noncancerous tissue demonstrated lack of the hormone expression. Thus, the study clearly shows that the expression of hCGβ is the feature of ovarian cancer tissue.

mRNA of hCGβ
Ovarian cancer
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