IMR Press / EJGO / Volume 25 / Issue 3 / pii/2004183

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Estrogen and progesterone expression of vessel walls with intravascular leiomyomatosis; Discussion of histogenesis

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1 Department of Pathology, and Obstetrics and Gynecology, Zeynep Kamil Maternity Hospital, Istanbul (Turkey)
2 Obstetrics and Gynecology, Zeynep Kamil Maternity Hospital, Istanbul (Turkey)
3 Department of Obstetrics and Gynecology, Acibadem Hospital, Istanbul (Turkey)
4 Department of Pathology, Haydarpasa Numune Hospital, Istanbul (Turkey)
Eur. J. Gynaecol. Oncol. 2004, 25(3), 362–366;
Published: 10 June 2004

We report seven cases of intravenous leiomyomatosis, Growth beyond the uterus occurred in two of the seven cases in the broad ligament. One 21-year-old patient is one of the youngest reported cases in the literature. Five patients had total abdominal hys­terectomy with removal of the adnexa and two patients underwent myomectomy. One of the myomectomy cases had abdominal hys­terectomy and bilateral salpingo-oophorectomy one year later due to recurrence. The other one was disease free six months after the operation. Vessel walls harboring intravascular tumor were investigated immunohistochemically for Factor VIII, CD 34, estro­gen and progesterone receptors with the hope of making the histogenesis of intravenous leiomyomatosis clear. Immunohistochem­ical analyses of estrogen receptors, progesterone receptors, vimentin, des min, smooth muscle actin, CD JO and h-caldesmon were performed on intravascular tumor cells. Endothelial and subendothelial cells expressed none to scant, very weak progesterone and estrogen receptor positivity. Intravas­cular tumor cells showed weak (10%) to strong (70%) progesterone receptor positivity and weak (10%) to strong (60%) estrogen receptor positivity. These results do not support the hypothesis of a vessel wall origin for intravenous leiomyomatosis.

Intravenous leiomyomatosis
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