European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Human chorionic gonadotropinbeta in endometrium cancer tissue
Purpose: Determination of the correlation between expression of human chorionic gonadotropin mRNA and serum free hCGb immunoreactivity in endometrial cancer tissue. Methods: The study included 56 patients with endometrial carcinoma Stages IB-Ill. The expression of mRNA hCGβ was determinated by the RT PCR method in 18 cases of cancerous and precancerous tissues. The serum-free hCGβ immunoreactivity was analyzed by sequential immunometric assay in all patients. Results: In 15 study specimens of endometrial carcinoma tissue mRNA of hCGβ was detected. Also in endometrial atypical hyperplasia, expression of hCGβ was found. Noncancerous tissue demonstrated lack of the hCGβ transcript. The serum immunoreactivity in the endometrial cancer group was detectable in 86% of cases. There were no significant differences between FIGO stages and grading. Conclusion: The results of the present study confirmed the presence of active genes of hCGβ in endometrial cancer tissue, even in precancerous changes. The serum immunoreactivity of free hCGβ is a less common feature and is not linked with tumor stage or grade in endometrial cancer patients.