IMR Press / EJGO / Volume 25 / Issue 2 / pii/2004161

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Sclerosing stromal tumors of the ovary: a clinicopathologic, immunohistochemical and cytogenetic analysis of three cases

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1 Pathology Department, Hippokrateion Hospital of Thessaloniki, Thessaloniki (Greece)
2 Department of Transplantation Surgery, Hippokrateion Hospital of Thessaloniki, Thessaloniki (Greece)
Eur. J. Gynaecol. Oncol. 2004, 25(2), 257–260;
Published: 10 April 2004

Sclerosing stromal tumors (SSTs) are uncommon ovarian neoplasms of the sex cord-stromal category, that usually occur below 30 years of age. In the present study three cases of SSTs, diagnosed during the last eight years in our hospital, were examined immuno­histochemically with stains for estrogen receptors, α and β progesterone receptors, and stains for markers that have been reported to be of use in the diagnosis of sex cord-stromal tumors. They were also examined by fluoresence in situ hybridization (FISH) for the presence of trisomy 12 and 7. Positivity for ERα was observed in a significantly larger number of cells than ERex. Positivity for calre­tinin and A103 was observed in tumor cells. In two cases 20-30% of the nuclei showed trisomy 12. No aberration of chromosome 7 was detected. The finding of increased ERβ expression needs further investigation.

Sclerosing stromal tumor
Estrogen receptor α
Estrogen receptor β
Progesterone receptor
Chromosome 12
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