European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Sclerosing stromal tumors of the ovary: a clinicopathologic, immunohistochemical and cytogenetic analysis of three cases
Sclerosing stromal tumors (SSTs) are uncommon ovarian neoplasms of the sex cord-stromal category, that usually occur below 30 years of age. In the present study three cases of SSTs, diagnosed during the last eight years in our hospital, were examined immunohistochemically with stains for estrogen receptors, α and β progesterone receptors, and stains for markers that have been reported to be of use in the diagnosis of sex cord-stromal tumors. They were also examined by fluoresence in situ hybridization (FISH) for the presence of trisomy 12 and 7. Positivity for ERα was observed in a significantly larger number of cells than ERex. Positivity for calretinin and A103 was observed in tumor cells. In two cases 20-30% of the nuclei showed trisomy 12. No aberration of chromosome 7 was detected. The finding of increased ERβ expression needs further investigation.