IMR Press / EJGO / Volume 24 / Issue 5 / pii/2003184

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

High-risk human papillomavirus type does not predict grade of cervical intraepithelial neoplasia

Show Less
1 Department of Pathology, University of Vermont, Burlington, VT, USA
2 Department of Biostatistics, University of Vermont, Burlington, VT, USA
Eur. J. Gynaecol. Oncol. 2003, 24(5), 373–376;
Published: 10 October 2003

Purpose of Investigation: The aim of this study was to examine whether HPV testing specificity for cervical intraepithelial neo­plasia (CIN) grades 2 or 3 could be improved by restricting the range of HPV types classified as 'high-risk' Methods: DNA was extracted from 28 CIN I, nine CIN II and 13 CIN III formalin-fixed, paraffin-embedded biopsies. HPV type was determined by General Primer mediated 5+/6+ PCR assay. Results: The prevalence of specific HPV types among the different grades of CIN and the relationship to the referral smear drng­nosis was examined. HPV type-16 alone was more highly associated with CIN grade (p < 0.0001; Specificity= 0.93; Sensitivity= 0.68) than was the group of HPV types collectively classed as high-risk (p = 0.025; Specificity = 0.23; Sensitivity = 1.00). Conclusions: These data suggest HPV testing specificity could be improved simply by including a separate test for HPV-16. In conjunction with previous studies, the data also suggests redefinition of the high-risk HPV category to take into account the differ­ing degrees of oncogenicity of high-risk HPV types.

Human papillomavirus
Cervical intraepithelial neoplasia
Cervical screening
Back to top