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European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Methylation: A second hit in the two-hit hypothesis
J. P. Geisler1,2,*, J. A. Rathe1, K. J. Manahan1, H. E. Geisler2
1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics Iowa City, IA, USA
2 Division of Gynecologic Oncology, St. Vincent Hospital and Health Services Indianapolis, IN, USA
Eur. J. Gynaecol. Oncol. 2003, 24(5), 361–361;
Published: 10 October 2003
This case illustrates that methylation of one BRCA I allele may serve as the second hit in a patient with a diploid locus and missense mutation on the other allele.