IMR Press / EJGO / Volume 24 / Issue 5 / pii/2003180

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Methylation: A second hit in the two-hit hypothesis

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1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics Iowa City, IA, USA
2 Division of Gynecologic Oncology, St. Vincent Hospital and Health Services Indianapolis, IN, USA
Eur. J. Gynaecol. Oncol. 2003, 24(5), 361–361;
Published: 10 October 2003

This case illustrates that methylation of one BRCA I allele may serve as the second hit in a patient with a diploid locus and mis­sense mutation on the other allele.

DNA silencing
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