IMR Press / EJGO / Volume 24 / Issue 1 / pii/2003104

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Pathological findings in early-stage endometrial cancer

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1 Department of 1Pathology and 2Obstetrics & Gynecology, Assaf Harofeh Medical Center; Zerifin, Affiliated with Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
Eur. J. Gynaecol. Oncol. 2003, 24(1), 18–20;
Published: 10 February 2003

Objective. The aim of this study was to assess the pathological characteristics of early-stage endometrial cancer, with regard to endometrioid versus serous papillary adenocarcinoma. Methods. Sixty-six cases of early-stage endometrial carcinoma were classified into two groups: group I - 36 cases of endome­trioid endometrial cancer, staged IA-IB and graded G, - G2; group II - 30 cases of Stage I serous papillary endometrial cancer. The pathological characteristics compared between the two groups included features such as tumor location in the uterine cavity, tumor focality, lymphovascular invasion, as well as the status of the uninvolved endometrium, adjacent to the tumor. Patient clinical cha­racteristics were obtained from the medical records. Results. Significantly more patients with endometrioid endometrial cancer were premenopausal (p < 0.0001), obese (p < 0.02), had hypertension (p < 0.00001) and familial cancer (p < 0.0001). On the other hand, significantly more patients with serous papil­lary cancer had another primary malignancy (p < 0.001). Considering the pathological characteristics, 75% of endometrioid as com­pared with 6.7% of serous papillary cancer cases were found in the upper uterine segment only (p < 0.0001). Multifocality was observed in 16.7% of endometrioid as compared with 100% of serous papillary cancer cases (p < 0.0001). Lymphovascular space invasion was absent in all cases of endometrioid cancer, while present in 90% of serous papillary cancer cases (p < 0.0001). Seventy­five percent of endometrioid and 100% of serous papillary cancer cases were associated with an atrophic endometrium. Conclusion. The clinical and pathological features of early-stage endometrial cancer differ according to the histological type of the cancer. The majority of endometrioid cancers are probably associated with an atrophic or normally cycling endometrium, and not with endometrial hyperplasia.

Early-stage endometrial cancer
Endometrioid endometrial cancer
Serous papillary endometrial cancer
Clinicopatho-logical findings
Endometrial hyperplasia
Atrophic endometrium
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