IMR Press / EJGO / Volume 23 / Issue 6 / pii/2002221

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Sialyltransferase family members and cervix squamous cell carcinoma

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1 Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Department of Medicine, Cheng Hsin Rehabilitation Center Institute of Clinical Medicine & Biochemistry National Yang-Ming University, Taipei (Taiwan)
Eur. J. Gynaecol. Oncol. 2002, 23(6), 514–518;
Published: 10 December 2002

Sialic acids including a number of their derivatives are ubiquitous at the terminal positions of the oligosaccharides of glycoproteins. The transfer of sialic acids from cystidme-5-monophospho-N-acetylneuraminic acid (CMP-NeuAc) to the terminal position of the carbohydrate group of glycoproteins and glycolipids is catalyzed by a family of sialyltransferases (STs). There is a large body of evidence to suggest that tumor cells have altered surface properties from their normal counterparts and that these chancres are partially due to altered sialo-glycoconjugates expressed on the plasma membrane and that altered sialylation (change in glycoprotein expression), which occurs during certain pathological processes, such as oncogenic transformation, tumor metastases, and invasion, is associated with enhanced ST activity. In this report we attempt to review the important findings in studing sialyltransferases of cervix squamous cell carcmoma.

Squamous cell carcinoma of the cervix
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