IMR Press / EJGO / Volume 23 / Issue 4 / pii/2002179

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Multidrug resistance gene-1 (Pgp) expression in epithelial ovarian malignancies

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1 Osmanga?i University Faculty of Medicine, Department of Obstetrics and Gynecology, Esk?ehir (Turkey)
2 Gynecologic Oncology Unit,  Esk?ehir (Turkey)
3 Department of Pathology, Esk?ehir (Turkey)
Eur. J. Gynaecol. Oncol. 2002, 23(4), 337–340;
Published: 10 August 2002

Objective: To assess the value of P-glycoprotein (Pgp) expression in advanced epithelial ovarian cancer with regard to clinico­pathological findings and disease prognosis. Methods: Twenty-four cases diagnosed as primary epithelial ovarian malignancies, between 1993-1999, were enrolled in this study. All of the cases had undergone cytoreductive surgery and an optimal staging procedure. Following cytoreductive surgery, in 18 patients, cisplatin+cyclophosphamide, and in six patients, cisplatin+paclitaxel combination chemotherapy regimens were initia­ted. After six courses of chemotherapy, cases were evaluated by pelvic examination, transvaginal ultrasound, pelviabdominal tomo­graphy and serum Ca-125 levels for the presence of residual disease. Following this evaluation residual tumor was detected in 14 cases and secondary cytoreductive surgery was undergone. In ten cases without any clinical and laboratory confirmation of the presence of tumor, second-look laparotomy was performed. In 24 epithelial ovarian cancer cases, both in primary or secondary cyto­reductive surgery, Pgp expression was determined by immunohistochemical methods. Results: Following primary surgery, in 25% (6/24) of cases, analysis of tumor specimens showed presence of Pgp expression. In cases recurring after first-line chemotherapy, Pgp expression was not statistically different in regard to chemotherapy regimen (p = 0.098). Pgp expression in tumoral tissues after chemotherapy did show a higher Pgp expression than before chemotherapy (p = 0.016). No significant correlation was relevant between Pgp expression and Ca-125 levels, histopathological differentiation, histologic subgroups of tumor, primary and residual tumor sizes and overall survival. Conclusion: In epithelial ovarian cancer, Pgp expression has no effect on overall disease survival.

Multidrug resistance
Epithelial ovarian cancer
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