IMR Press / EJGO / Volume 23 / Issue 4 / pii/2002170

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Content of folic acid and free homocysteine in blood serum of human papillomavirus-infected women with cervical dysplasia

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1 I Clinic of Obstetrics and Gynaecology, Lublin Medical Academy, Lublin (Poland)
2 Institute of Biology, Maria Curie Sklodowska University, Lublin (Poland)
3 Department of Molecular Virology, Adam Mickiewicz University, Poznan (Poland)
4 Department of Pathomorphology, Lublin Medical Academy, Lublin (Poland)
Eur. J. Gynaecol. Oncol. 2002, 23(4), 311–316;
Published: 10 August 2002

The authors estimated the concentrations of folic acid and free homocysteine in the blood serum of women with CIN III (cervi­cal intraepithelial neoplasia-Burghard’s classification) infected with DNA HPV (human papillomaviruses) of type 16 and/or 18. The control group consisted of 49 patients with normal cytological smears without HPV infection. Types 16 and/or 18 DNA HPV were found in 50 patients. This women qualified for the studied group. The sequence of DNA HPV type 16 and/or 18 was identified with the PCR method (polymerase chain reaction). The high-performance liquid chromatography (HPLC) method was employed to eva­luate the levels of folic acid and free homocysteine in the blood serum of the examined patients. Significantly lower levels of folic acid and higher levels of free homocysteine were observed in the blood serum of HPV-positive patients with CIN III. The correla­tion was found between serum concentrations of folic acid and free homocysteine in both groups.

Tonic acid
Cervical dysplasia
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