European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Expression of NM23 and tenascin in invasive ductal carcinomas of the breast
Objective: In this series of ductal carcinoma of the breast, immunoexpression of antimetastasis gene nm23 and tenascin was examined and the role in prognosis was investigated by correlation with the tumour grade and stage, and ER/PR immunoexpression. Material and Methods: In this study 27 ductal carcinomas of the breast were analysed for expression of tenascin and nm23 antimetastasis genes by immunohistochemistry. Results: The results of our study revealed a statistically significant correlation between nm23-H1 immunoexpression and lymph node metastasis. We also found a statistically significant correlation between tenascin and nm23-H1 immunoexpression. Our results suggest that tenascin limits tumour spread. Conclusion(s): Antimetastasis gene expression can be used in predicting lymph node metastasis in ductal carcinomas of the breast.