IMR Press / EJGO / Volume 23 / Issue 3 / pii/2002157

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Malignant ovarian germ cell tumors: the KK Hospital Experience

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1 Gynaecological Oncology Unit, KK Women’s and Children’s Hospital (Singapore)
2 Department of Histopathology, KK Women’s and Children’s Hospital (Singapore)
Eur. J. Gynaecol. Oncol. 2002, 23(3), 251–256;
Published: 10 June 2002

Ovarian germ cell malignancies pose a therapeutic challenge especially amongst young patients. This is a retrospective review of 49 patients treated for such malignancies at KK Women’s and Children's Hospital over a 13-year period. The relative proportion of such tumors was 6.2%. Age at presentation ranged from 14 to 51 years (mean 25.4 years). Forty-nine percent of tumors were imma­ture teratomas and 81.6% had stage I disease. All patients had surgery initially and 67.3% required postoperative adjuvant che­motherapy. The patients were followed-up for one to 145 months (mean 51.6 months). All the 87.8% of patients on follow-up are alive and disease-free. There was one recurrence. Five patients had eight successful pregnancies, with no congenital anomalies. Mean duration when menstruation was resumed and regular was 2.5 and 3.5 months, respectively. With combination chemotherapy and conservative surgery, the outlook for patients is excellent, with emphasis on preservation of ovarian function and fertility.

Germ cell tumor
Germ cell malignancy
Ovarian germ cell
Malignant ovarian germ cell tumor
Fertility sparing surgery
Menstrual function
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