IMR Press / EJGO / Volume 23 / Issue 1 / pii/2002112

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Comparison of two procedures for sentinel lymph node detection in patients with endometrial cancer: A pilot study

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1 Department of Obstetrics and Gynaecology, Endoscopic Training Centre,  Kladno (Czech Republic)
2 Department of Biochemistry and Statistical Analysis, Baby Friendly Hospital, Kladno (Czech Republic)
Eur. J. Gynaecol. Oncol. 2002, 23(1), 53–57;
Published: 10 February 2002

Objective: The purpose of this study was to assess the feasibility and contribution of two intraoperative procedures of lymphatic mapping and sentinel node detection using a blue dye in surgically-staged patients with early stage endometrial cancer. Methods and Materials: In 25 cases of endometrial cancer, patent blue-V was injected into the subserosal myometrium (13 cases, SM group) or cervico-subserosal myometrium (12 cases, CSM group) during a surgical staging procedure. Laparoscopically-assi­sted vaginal hysterectomy and pelvic lymphadenectomy were completed successfully in 23 women out of 24 laparoscopically-staged patients (95.8%). One patient with FIGO stage IIa was indicated for a radical abdominal surgery. Results: A deposition of the blue dye-was found in at least one pelvic lymph node (LN) in eight out of 13 cases (61.5%) in the SM group compared with ten out of 12 cases (83.3%) in the CSM group (p = 0.378). The mean number of dye-colored LN (DCLN) was 1.15 (SM group) and 2.5 (CSM group), respectively (p = 0.05). The rate of DCLN/LN was 15/188 (SM group) versus 30/190, respectively (p = 0.03). An uptake of the blue bye was observed in a total of 45 out of 388 LN. Conclusion: An intraoperative combination of cervico-subserosal myometrium application of the blue dye allows successful detection (83.3%) of sentinel LN in patients with endometrial cancer. Comparing SM and CSM groups the statistical significant dif­ference was found in the DCLN/LN rate and mean number of sentinel lymph nodes (p = 0.03, p = 0.05, respectively). Clinical vali­dity of this surgical procedure must be assessed prospectively.

Sentinel lymph node detection
Endometrial cancer
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