IMR Press / EJGO / Volume 23 / Issue 1 / pii/2002111

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

The effects of tamoxif en on rat skin

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1 Department of Dermatology, University of Gaziantep Faculty of Medicine, Gaziantep (Turkey)
2 Department of Histology & Embryology, University of Gaziantep Faculty of Medicine, Gaziantep (Turkey)
Eur. J. Gynaecol. Oncol. 2002, 23(1), 50–52;
Published: 10 February 2002

Background: Tamoxifen (Tx) is used mostly in the treatment of breast and gynecological cancers. It is also widely used in the treatment of different dermatological disorders. However. its effects on skin have not been investigated previously.Objective: To investigate the effects of Tx administration on rat skin. Methods: Forty Spraque-Dawley female newborn rats were separated into two control groups and two experimental groups (n = 10). One day after birth. the control groups of newborn rats were given 0.02 ml saline subcutaneously (sc) daily whereas experi­mental litters were treated with 100 µg Tx citrate in 0.02 ml saline sc daily for five days. The first control group and experimental group of rats were anesthetized at 21 days whereas the second control group and experimental group of rats were anesthetized on the 28th day. Histopathological assessments were made and compared with the control groups. Results: Abnormal hair follicles were observed in both experimental groups of rats. Epidermal atrophy together with increased dermal fibrosis was more prominent in the first experimental group. Dermal fibrosis and lymphohistiocytic inflammatory cell infil­tration were found to be prominent around the hair follicles in the second experimental group. Conclusion: Considerable harmful effects of Tx administration were observed on rat skin.

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