IMR Press / EJGO / Volume 22 / Issue 6 / pii/2001205

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Transvaginal ultrasonography and hysterosonography to monitor endometrial effects in tamoxifen-treated patients

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1 Department of Obstetrics and Gynecology, University of Genova, Italy
2 Medical Oncology, S. Croce General Hospital, Cuneo, Italy
3 Medical Oncology Division, National Institute for Cancer Research, Genova, Italy
Eur. J. Gynaecol. Oncol. 2001, 22(6), 441–444;
Published: 10 December 2001

Purpose of investigation: Our purpose was to evaluate if, during tamoxifen treatment, hysterosonography may increase diagnos­tic accuracy when compared with transvaginal ultrasonography and to identify, when and in how many cases, further biopsies may be avoided. Methods: We performed transvaginal utrasound in 310 asymptomatic women under tamoxifen treatment, using 8 mm endome­trial thickness as the cut-off. One hundred and seven patients with an endometrium thicker than 8 mm were enrolled for hystero­sonography. parameters to be evaluated by transvaginal ultrasound and hysterosonography were thickness and structural features of the endometrium. It was possible to compare ultrasound examinations with histopathological findings obtained by biopsy in 83 patients. Results: Globally only ten patients from the study cohort had true endometrial pathology. Based on structural features of the endo­metrium, we found a global accuracy of 95.6%, with 2.8% false negatives and 4.1 % false positives. Conclusion: Hysterosonography can increase diagnostic accuracy during tamoxifen treatment and may allow further invasive investigations to be avoided in patients with suggestive hysterosonographic features.

Transvaginal ultrasound
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