IMR Press / EJGO / Volume 22 / Issue 6 / pii/2001202

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Immunohistochemical evaluation of a new epithelial antigen, Ber-EP4, in ovarian cancer: preliminary results

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1 Department of Pharmacology, Gynaecology and Obstetrics, University of Sassari, Italy
2 Institute of Pathology, University of Sassari, Italy
Eur. J. Gynaecol. Oncol. 2001, 22(6), 433–435;
Published: 10 December 2001

Objective: To assess the immunohistochemical expression of Ber-EP4, a new epithelial antigen m ovarian cancer. Methods: We studied 25 cases of ovarian cancer in which Ber-EP4, CEA and CA 125 were investigated by an immunohistochemical method. We evaluated the correlations between immunohistochemical positivity and grading, histotype and stage of disease. Results: CEA was positive in 5 out of 25 cases (20%), CA-125 in 17 out of 25 cases (68%) and Ber-EP4 in 14 out of 25 cases (56%). Ber-EP4 was mainly present in mucinous tumors in comparison to serous tumors (78.6% vs. 50%). Ber-EP4, as well as CA-125, were directly proportional to tumor differentation (70% of positivity in G 1 vs 37.5% in G3 for the former and 80% in GI vs 50% in G3 for the latter, respectively), whereas CEA showed no relevant difference regarding the grading. There were no differen­ces among the three antigens studied with regard to clinical stage. Conclusions: In our study Ber-EP4 was positive in 14 out of 22 cases (63.6%) of the primary epithelial ovarian cancers studied The presence of this antigen seems to be related to histotype and grading but not to clinical stage.

Epithelial antigen
Ovarian cancer
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