IMR Press / EJGO / Volume 22 / Issue 5 / pii/2001182

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Herbal complex suppresses telomerase activity in chemo-endocrine resistant cancer cell lines

Show Less
1 Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu City, Japan
Eur. J. Gynaecol. Oncol. 2001, 22(5), 347–349;
Published: 10 October 2001

A herbal complex consisting of Hoelen, Angelicae radix, Scutetlariae radix and Glycyrrhizae radix suppressed cell viability and telomerase activity in hormone-refractory and chemo-resistant cancer cell lines, namely poorly differentiated uterine endometrial cancer cell line AN3 CA, adriamycin-resistant breast cancer cell line MCF7/ADR and cisplatin-resistant ovarian cancer cell line A2780. Furthermore, the herbal complex suppressed the expression of the full length of human telomerase reverse transcriptase (hTERT), which is related to telomerase activity. This indicates that the herbal complex can suppress the tumor growth of chemo­endocrine resistant cancers, at least in part via suppression of telomerase activity associated with down-regulated hTERT.

Herbal complex (Hoelen
Angelicae Radix
Scuteltariae Radix and Glycycrrhizae Radix)
Telomerase activity
Back to top