IMR Press / EJGO / Volume 22 / Issue 4 / pii/2001159

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Distinguished Expert Series

Heat shock protein expression and immunity: relevance to gynecologic oncology

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1 Divison of Immunology and lnfectious Diseases - Department of Obstetrics and Gynecology Weill Medical College of Cornell University New York, New York, USA
Eur. J. Gynaecol. Oncol. 2001, 22(4), 249–256;
Published: 10 August 2001

Heat shock proteins function as molecular chaperones, guiding the transport, assembly and degradation of intracellular poly­peptides. Under the influence of non-physiological conditions heat shock protein synthesis is accelerated to aid cell survival. Thus, over-production of heat shock proteins protects malignantly transformed cells from apoptotic cell death and fosters resistance to chemotherapeutic agents and irradiation. Individual heat shock proteins, such as the 27 kDa (hsp27) and 70 kDa (hsp70) heat shock proteins, their antibodies and/or genotypes of polymorphic genes may have diagnostic and prognostic value for different gynecolo­gic malignancies, The possible exploitation of the properties of heat shock proteins for development of unique anti-cancer therapies in individuals resistant to traditional treatment is currently under active investigation.

Heat shock proteins
Gynecologic cancers
Gene polymorphism
Immune response
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