IMR Press / EJGO / Volume 22 / Issue 1 / pii/2001111

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Increased expression of Interleukin- I beta is associated with persistence of the disease and invasion in complete hydatidiform moles (CHM)

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1 Research Division, Regional Cancer Centre, Trivandrum, India
2 Department of Gynaecology, SAT Hospital, Trivandrum, India
3 Department of Medical Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
Eur. J. Gynaecol. Oncol. 2001, 22(1), 50–56;
Published: 10 February 2001

Complete hydatidiform moles (CHM), a post-conceptual pathologic condition of the placenta, have a high prevalence rate (12/1,000 deliveries) in Kerala, India. This study addresses the expression of IL-1 alpha and beta by immunohistochemistry in relation to persi­stence and invasion of the disease. Mild to moderate expression of IL-1 alpha in the villous cytotrophoblasts, syncytiotrophoblasts and decidua of the first trimester in the normal placenta and all gestational ages in the molar placenta were observed. IL-1 beta expression was observed in the extravillous trophoblasts, syncytiotrophoblasts and decidua in both the normal and molar placentae and also in the villous cytotrophoblasts and the stromal Haufbaur cells in molar placentae. Strong expression of IL-1 beta in the placenta suggests its involvement in placental physiology supporting earlier reports. Higher expression of IL-1 beta correlated well with the invasive and persistent nature of the tumour and holds potential as a marker of persistence and invasion in CHM.

Complete hydatidiform moles
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