IMR Press / EJGO / Volume 21 / Issue 6 / pii/2000238

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Malignant fibrous histiocytorna of the uterus

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1 Departmnet of Pathology, Cancer Research Center, Moscow, Russia
2 Departmnet of Pathology, Medical School, University of Valencia, Valencia, Spain
Eur. J. Gynaecol. Oncol. 2000, 21(6), 588–590;
Published: 10 December 2000

A 56-year-old menopausal woman was admitted to hospital because of vaginal spotting of several months duration. The patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and omentectomy. On divalving, the uterus showed an ulcerated nodule 8 cm in diameter, protruding into the uterine cavity from the posterior wall. Histologically the tumor had a typical morphology of malignant fibrous histiocytoma (MFH). Multinucleated giant cells were strongly positive for CD 68 alpha antichymotripsin and alpha antitrypsin. Mononuclear cells also showed the same immunohistochemical pattern though less intensive than the giant cells. The cells were uniformly negative for S-100 protein, myoD1, myogenin desmin and actin. Electron microscopical investigation disclosed ultra­structural features compatible with the histiocytic nature of the tumor. Thirty-three months later the patient was free of disease.

MFH of the uterus
Uterine sarcomas
Soft tissue sarcomas
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