IMR Press / EJGO / Volume 21 / Issue 5 / pii/2000221

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Expression of bcl-2 and bax in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix

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1 Department of Pathology, University of Patras Medical School, Patras, Greece
2 Department of Obstetrics and Gynecology, University of Patras Medical School, Patras, Greece
3 Department of Pathology, Department of Obstetrics and Gynacology Helena Venizelou Hospital, Athens, Greece
Eur. J. Gynaecol. Oncol. 2000, 21(5), 494–498;
Published: 10 October 2000

Bcl-2 protein together with the pro-apoptotic protein bax, are thought to function by forming homo- and heterotypic dimers which control the progression to apoptosis. In this immunohistochemical study we investigated the expression of bcl-2 and bax apoptosis related proteins in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the uterine cervix. Twenty-four cervical intraepithelial neoplasias grade 1-2 (CINI/II), 38 grade 3 (CIN III), and 53 invasive squamous cell carci­nomas (ISCC) were investigated by immunohistochemical staining for bcl-2 and bax protein. Bcl-2 immunoreactivity was found in five of the 24 CINI/II cases (20.8%), 18 of 38 CIN III cases (47.4%) and nine of 53 ISCC cases (17%). The positivity for CIN III was significantly higher than for CINI/II or ISCC (p = 0.0351 and p = 0.0018, respectively). The percentage of bax immunopositivity was somewhat higher in CIN III than in CIN I/II but this slight difference was not stati­stically significant. Correlation of the immunostaining results with tumor grade revealed a significant difference for bcl-2 which was more frequently immunopositive in well-differentiated tumors than in poorly-differentiated tumors. There was no significant rela­tion between bax expression and tumor differentiation. Our results suggest that alterations of bcl-2 and bax expression may occur as a relatively early event in cervical tumorigenesis.

Cervical intraepithelial neoplasia
Squamous cell carcinoma
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