IMR Press / EJGO / Volume 20 / Issue 2 / pii/1999131

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Pilot study on the treatment of cyclical mastodynia with Quinagolide

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1 Jaso Maternity Hospital, Athens, Greece
2 Hippokratio Athens Hospital, Athens, Greece
3 Areteio University Hospital, Athens, Greece
Eur. J. Gynaecol. Oncol. 1999, 20(2), 117–121;
Published: 10 April 1999

In a pilot clinical trial on 52 patients, 75μg Quinagolide given once per day was administered for the treatment of cyclical mastodynia. Linear analogue charts were used for the assessment of response. Decrease in breast pain, heaviness, tenderness and serum prolactin level on the one hand, and increases in the serum estradiol and progesterone levels on the other hand were noted after 3 and 6 months administration, and were statistically significant. Statistical analysis was performed by Paired t-test or Wilcoxon test, One-Way Anova Repeated Measures and Wilcoxon test and analysis of Covariance model. The beneficial effect of Quinagolide also lasted after the cessation of treatment. Fourteen patients dropped out during treatment. Adverse effects like nausea, low blood pressure, dizziness and constipation were rarely reported.

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