IMR Press / EJGO / Volume 19 / Issue 5 / pii/1998206

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Tarnoxifen-induced endornetrial polyp. A case report and review of the literature

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1 Departments of Surgery, Tzanion General Hospital, Piraeus, Greece
2 Pathology, Tzanion General Hospital, Piraeus, Greece
Eur. J. Gynaecol. Oncol. 1998, 19(5), 476–478;
Published: 10 October 1998

A case of an endometrial polyp which developed in a 74-year-old woman treated with tamoxifen for 15 years after breast cancer surgery was the stimulus for this brief and concise review of the endometrial changes caused by anti-estrogen treatment in post­menopausal women with breast cancer. Tamoxifen therapy has been associated with the development of endometrial polyps, hyperplasia and adenocarcinoma possibly mediated through its agonistic estrogenic properties. Hysteroscopy follow-up should be performed in this group of patients and hysteroscopy should be done before the beginning of therapy and repeated once a year during the treatment.

Breast cancer
Endometrial changes
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