IMR Press / EJGO / Volume 19 / Issue 5 / pii/1998204

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

HPV and intraepithelial neoplasia recurrent lesions of the lower genital tract: assessment of the immune system

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1 II Clinic of Obstetrics and Gynecology, University of Rome “La Sapienza”, Italy
2 Infectious Disease Dept., University of Rome “La Sapienza”, Italy
Eur. J. Gynaecol. Oncol. 1998, 19(5), 466–469;
Published: 10 October 1998

Objective: To evaluate the immune state in patients with genital relapse HPV and intraepithelial lesions of the lower genital tract. Method: Forty-three patients were selected. Twenty-one were affected by recurrent HPV infection either alone or combined with intraepithelial neoplasia treated by laser surgery, and 22 had been previously-treated and clinically cured without recurrence during a follow-up from 18 to 24 months. The diagnostic protocol included colposcopy with eso- and endocervical cytology histologically confirmed by directed biopsy Afterwards patients underwent a systemic immunogenic evaluation Results: NK cell reduction was strictly related to HPV infection associated with intraepithelial lesions; B-lymphocyte reduction was percentually greater in patients affected by HPV alone; activation of R-IL2 increased in a percentage overlapping in the two groups indicating patient reaction to the virus. Conclusion: Our study supports the theory that immune response directed against viral antigens is one of the most important effec­tors in the control of HPV infections and that HPV is the cause of a systemic rather than local lesion.

Intraepithelial noeplasia
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