IMR Press / EJGO / Volume 19 / Issue 5 / pii/1998197

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Case Report

Masculinizing sclerosing stromal cell tumor in pregnancy: report of a case and review of the literature

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1 Massachusetts General Hospital, Division of Gynecologic Oncology, Boston, MA, USA
2 Massachusetts General Hospital, Division of Cytopathology, Boston, MA, USA
Eur. J. Gynaecol. Oncol. 1998, 19(5), 441–443;
Published: 10 October 1998

Purpose: To report a case of sclerosing stromal cell tumor of the ovary in pregnancy and to review the literature of this rare ovarian tumor. Methods: The patient's office record and hospital record were reviewed. Gross and microscopic pathology were reviewed by one gynecologic pathologist. A Medline literature search and literature review were performed. Results: Over eighty cases of sclerosing stromal cell tumor of the ovary have been reported in the literature since the definition of this pathologic condition in 1973. Only five cases have been reported during pregnancy and only two of these resulted in maternal virilization. This report describes severe maternal virilization with birth of a non-virilized female infant. Conclusion: Sclerosing stromal cell tumor of the ovary can result in severe virilization via androgen production. Surgery with removal of the involved ovary is required for diagnosis and cure. Prognosis is excellent.

Stromal cell tumor
Ovarian neoplasm
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