IMR Press / EJGO / Volume 19 / Issue 3 / pii/1998157

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Management of cervical intraepithelial neoplasia of the uterine cervix: 110 cases treated by cold-knife conization

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1 Institute of Gynaecology and Obstetrics, Catholic University of Sacred Heart, Rome, Italy
2 Division of Human Pathology and Histology, Catholic University of Sacred Heart, Rome, Italy
3 Division of Human Pathology and Histology, S. Giovanni Evangelista Hospital, Tivoli, Rome, Italy
4 Institute of Internal Medicine, Catholic University of Sacred Heart, Rome, Italy
Eur. J. Gynaecol. Oncol. 1998, 19(3), 253–256;
Published: 10 June 1998

Purpose of investigation: The purpose of this study was to evaluate treatment by cold-knife-conization in women carriers of cer­vical intraepithelial neoplasia (CIN). Methods: The histologic findings of pre-clinical neoplasia of the cervix after conization were compared to the previous findings of cytology, colposcopy and punch-biopsy in 110 women examined between 1985 and 1995. The chi square test (χ2) was used for the statistical analysis. Results and conclusions: A close correlation is clinically important where complementary roles of these three methods are used to identify lesions suitable for local ablative therapy. The Pap test alone is no longer sufficient for the screening of the pre-cance­rous lesion of the cervix and colposcopy is compulsory each time the smear is inadequate or altered. Conization permitted us to single out 13 (11.8%) cases of carcinoma. After cold-knife conization we had six (5.4%) recurrences within two years and two (1.8%) within three years. Our data show that conservative therapy by conization in women with CIN reduces the risk of invasive cancer of the cervix but careful follow-up of these patients is essential.

Cold-knife conization
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