IMR Press / EJGO / Volume 19 / Issue 3 / pii/1998154

European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with S.O.G.

Original Research

Well-differentiated versus less-differentiated endometrial carcinoma

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1 Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Zerifin, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Istrael
Eur. J. Gynaecol. Oncol. 1998, 19(3), 242–245;
Published: 10 June 1998

The aim of this study was to compare well-differentiated (grade l) and less-differentiated (grades 2 and 3) endometrial carcinoma, concerning clinical risk factors, presenting symptoms and operative findings. Seventy-one surgically staged endometrial carcinoma cases were reviewed and retrospectively divided according to tumor diffe­rentiation into two groups: grade 1 cases (Group I; n = 40) and grade 2 and 3 cases (Group II; n = 31). No difference was found between the two groups when comparing patient age, gravidity and parity, history of hypertension, dia­betes or other malignancies, duration of menopause, number of patients receiving hormonal replacement therapy and histological type of tumor. There was also no difference in presenting symptoms or in duration of uterine bleeding up to the diagnosis of endo­metrial carcinoma. On the other hand, patients with well-differentiated tumors, as compared to patients with less-differentiated endo­metrial carcinoma, were significantly more obese (p < 0.02), had a smaller uterus (p < 0.01) and presented with less advanced stage disease (p < 0.0005). The fact that the age of the patients, as well as the duration of uterine bleeding before diagnosis, was similar in both groups may indicate that more advanced cases, as in group II, represent originally a more aggressive tumor rather than progression from a well­differentiated disease. This hypothesis needs further research.

Endometrial carcinoma
Grade of differentiation
Patient characteristics
Clinical presentation
Intraoperative findings
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