European Journal of Gynaecological Oncology (EJGO) is published by IMR Press from Volume 40 Issue 1 (2019). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.
Expression of p53 protein in borderline epithelial ovarian tumors: a clinicopathologic study of 39 cases
Objective: To evaluate the expression of p53 protein in borderline ovarian tumors and its correlations with the clinicopathological parameters. Study design: p53 protein was detected by immunoperoxidase in 79 ovarian tumors (39 borderline, 20 malignant, 20 benign). p53expression was compared to histological type, FIGO stage, age, presence of ascites: recurrence and patient smvıval. Results: The median value of quantitative p53 immunopositivity was: 0.80 ± 0.42 in ovaıan cancers, 0 ± 0.24 m borderlme tumors and 0 ± 0.16 in benign tumors (p = 0.001). In borderline tumors, no correlation existed between p53 expression and the histological or clinical parameters. In malignant tumors, no correlation existed between the expression of p53 and patient survival. Conclusion: We found no correlation between p53 immunopositivity and clinicopathological parameters in carcinomas and borderline tumors of the ovary. p53 immunopositivity may help in distinguishing borderline tumors from ovarian cancers.